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Lead
Johns Hopkins University
The main cognitive task of interest in this study is the N-back task because of the observed attenuation of prefrontal and parietal cortical activity after nimodipine administration in healthy subjects. Investigators hypothesize that acute nimodipine administration will improve cortical activation, which will lead to improved cognitive performance. The current study will provide insight whether nimodipine or another calcium channel blocker could be used as a treatment approach to alleviate cognitive deficits in patients with schizophrenia.
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
This study will recruit patients with schizophrenia and/or schizoaffective disorder
You may not be if
past or current neurological disorder (including stroke, brain tumor, epilepsy, Alzheimer's, Parkinson's or Huntington's disease)
uncontrolled medical disorder
current or past hypotension
head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma
positive pregnancy test, or currently breast feeding
having an adverse reaction to nimodipine, or other calcium channel blocker
