Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Assistance Publique Hopitaux De Marseille
The present study is an opportunity to assess grey matter damage at the earliest phase of MS allowing to a better understanding of its origins and its impact and disease severity. This study is a preliminary longitudinal study to precisely depict the kinetic of grey matter damage and the links with disease aggravation. Thirty MS patients without time and spatial dissemination criteria (only one symptomatic MRI lesion detected) but with oligoclonal bands detected on cerebro spinal fluid analysis will be included for a monocentric transversal MRI study at 7T to assess grey matter injury. Clinical and neuropsychological assessments will be performed in the population the same day of a multi-parametric MRI. A longitudinal clinical and MRI follow up will be performed during 2 years.
Age
18–50
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
First presumed inflammatory demyelinating event in the central nervous system involving either the optic nerve, the spinal cord, a brain hemisphere, or the brainstem without spatial and time dissemination criteria
Oligoclonal bands on CSF analysis
Age between 18 and 45
No previous history of neurological symptoms suggestive of demyelination
No steroids in the month before MRI
First MRI within six months after the first clinical episode
You may not be if
Possible alternative diagnoses
Previous history of neurological or psychiatric disease
Previous administration of immunosuppressive drugs
Pregnancy
Patient unable to give his consent for the study or patient under tutorship
Clareo Health | Grey Matter Damage at the Earliest Phase of Multiple Sclerosis : a Longitudinal 7T MRI Study
