Exercise for Advanced Prostate Cancer: a Multicomponent Feasibility Trial

Inclusion Criteria

• •Histologically documented adenocarcinoma of the prostate with progressive systemic metastatic disease despite castrate levels of testosterone (\<50ng/dL).
• •At enrolment, patients must have demonstrated progressive disease since the most recent change in therapy.
• •Patients must be on ADT with a GnRH agonist/antagonist or prior bilateral orchiectomy. All patients must be on ADT during the study period.
• •≥ 4 weeks since last surgery and fully recovered.
• •No known contraindications to moderate intensity exercise such as (but not limited to) brain metastases, acute congestive heart failure, unstable angina, serious or non-healing wound, peripheral neuropathy greater than or equal to Grade 3. Recent myocardial infarction.
• •Age ≥ 18 years.
• •ECOG performance status 0-2.
• •Medical clearance by treating clinician.