Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

Exclusion Criteria

• •1. Current substance use disorder by DSM-5 in the past 3 months (except alcohol, tobacco, or cannabis)
• •2. Current or past history of psychotic features or psychotic disorder
• •3. Current or past history of delirium or dementia
• •4. Current uncontrolled hypertension (systolic BP \> 170 mm Hg or diastolic BP \> 100 mm Hg)
• •5. Unstable medical condition or allergy to ketamine, naltrexone, or lorazepam---clinically determined by a physician
• •6. Imminent suicidal or homicidal risk
• •7. Pregnant or nursing women, positive pregnancy test, or inadequate birth control methods in women of childbearing potential
• •8. Positive opioid or illicit drug screen test (except marijuana)
• •9. Opioid use within 10 days prior to study medication (injectable naltrexone) or risks for opioid use during the study
• •10. Liver enzymes that are three times higher than the upper limit of normal