Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Radboud University Medical Center
With
ZonMw: The Netherlands Organisation for Health Research and Development
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. ≥18 years old
2. Eligible for treatment with pemetrexed-based chemotherapy
3. Creatinine clearance \>45ml/min
4. Eastern Cooperative Oncology Group (ECOG) performance score of 0-2
5. Subject is able and willing to sign the Informed Consent Form
You may not be if
1. Conditions that affect haemostasis in a way that blood drawing is complicated (to be assessed by physician)
2. Contraindications for treatment with pemetrexed in line with the summary of product characteristics (SmPC) (except for creatinine clearance \<45 ml/min in IMPROVE-I)
1. Hypersensitivity to the active substance or to any of the excipients
2. Pregnancy or lactation
3. Concomitant yellow fever vaccine
3. The presence of clinically relevant pharmacokinetic interactions, according to the current SmPC
Clareo Health | Dose Individualization of Pemetrexed - IMPROVE-II
