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fMRI Analysis of Aging and Awareness in Conditioning | Clinical Trials | Clareo Health

ACTIVE_NOT_RECRUITINGNA

fMRI Analysis of Aging and Awareness in Conditioning

Functional Magnetic Resonance Imaging (fMRI) Analysis of Aging and Awareness in Conditioning

NCT03655769•Johns Hopkins University

Summary

Cathodal Transcranial direct current stimulation (tDCS) was administered to the right parietal region in order to determine if this stimulation could disrupt awareness of the conditioned stimulus (CS) - unconditioned stimulus (US) relationship in a classical conditioning experiment.

Eligibility

Age

20 - 30 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Educational attainment of at least eight years and English as the native language
•Mini-Mental State Examination (MMSE) score of 26
•Normal episodic memory (i.e., CERAD word List Recall \> 5)
•Informed consent; 5) age of 20-30

Exclusion Criteria

•Disturbed consciousness
•Other neurological or systemic disorder which can cause dementia or cognitive dysfunction
•Prior history of a major psychiatric disorder
•History of definite stroke
•Focal lesion on MRI exam
•Use of anxiolytic, antidepressant, neuroleptic, or sedative medication
•Predominately left-handed
•Has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).

Key Dates

Start Date

November 9, 2010

Primary Completion Date

December 31, 2026

Completion Date

December 31, 2026

Last Updated

December 11, 2025

Enrollment

ESTIMATED participants

Conditions

Transcranial Direct Current Stimulation

Interventions

transcranial direct current stimulation

DEVICE

sham transcranial direct current stimulation

DEVICE

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Autism Spectrum Disorder (ASD)Transcranial Direct Current Stimulation (tDCS)+1 more

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RECRUITINGNA

High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease

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Transcranial Direct Current StimulationFunctional Magnetic Resonance Imaging+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

fMRI Analysis of Aging and Awareness in Conditioning

Inclusion Criteria

Exclusion Criteria

Resting-State Functional Connectivity as a Predictor of tDCS Effects in Adolescents With Autism Spectrum Disorder

High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease

Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Depressive Disorder

Clinical Efficacy and Mechanism of High Definition tDCS Based on dmPFC in the Intervention of Chronic Insomnia

Promote Brain Resilience for the Coronavirus (COVID-19) Pandemic

Efficacy of tDCS to Enhance Virtual Reality Exposure Therapy Response in Acrophobia