The First Affiliated Hospital with Nanjing Medical University
30 patients with MOH，30 patients with episodic migraine and 30 age-matched healthy volunteers were recruited in the study. A series of neuropsychological test scale including Hospital Anxiety and Depression Scale (HADS), Pittsburgh sleep quality index (PSQI) and Leeds Dependence Questionnaire (LDQ) were evaluated among all the recruited. Blood samples were taken at 10 a.m. and centrifuged. The serum was separated and collected at -70 °C for the measurement of melatonin .
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Subject has medication overuse headache. Headache occurring on 15 or more days per month for more than 3 months. The number of medication days ≥10 days/month for triptans, ergotamine, opioids, combination analgesics, or multiple drug classes not individually overused; ≥15 days/ month for simple analgesic
Subject has had 1-8 migraines per month over the previous 3 months
Sign the informed consent
You may not be if
Subjects combine with other pain syndromes and long-term oral analgesics are needed
