Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
P. Verschueren
With
Belgium Health Care Knowledge Centre
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18 years and older
Diagnosis of RA as defined by the American College of Rheumatology (ACR)/ European League Against Rheumatism (EULAR) 2010 criteria for early RA
Early RA defined by a diagnosis made ≤ 1 year ago.
Use a reliable method of contraception for women of childbearing potential to be evaluated as in daily clinical practice
Able and willing to give written informed consent and to participate in the study
Understanding and able to write Dutch or French
You may not be if
Previous treatment with:
* Methotrexate (MTX) or leflunomide
* cyclophosphamide, azathioprine or cyclosporine
* sulphasalazine (SSZ) for more than 3 weeks
* hydroxychloroquine for more than 6 weeks
* oral Glucocorticoids (GC) for more than 4 weeks within 4 months before screening
* oral GC at a daily dosage of more than 10 mg prednisone equivalent within 4 weeks before baseline
* oral GC at a daily dosage equal to or less than 10 mg prednisone equivalent within 2 weeks before baseline
* intra-articular GC within 4 weeks before BL
* an investigational drug for the treatment/prevention of RA
History of chronic heart failure
History of severe infections or chronic infection
History of malignant neoplasm within 5 years
Contra indications for GC
Contra indications for TNF blocking agents
Contra indications for MTX or leflunomide
Psoriatic Arthritis
Underlying cardiac, pulmonary, metabolic, renal or gastrointestinal conditions, chronic or latent infectious diseases or immune deficiency which in the opinion of the investigator places the patient at an unacceptable risk for participation in the study
Pregnancy, breastfeeding or no use of a reliable method of contraception for woman of childbearing potential (as in daily clinical practice)
Alcohol or drug abuse
Active tuberculosis (TB)
Latent TB unless adequate prophylactic treatment is given according to local guidelines
