Eus-guided Cryothermal Ablation in Stage III Pancreatic Adenocarcinoma

Inclusion Criteria

• •Only patients with pathologically proven, locally advanced, unresectable pancreatic adenocarcinoma will be selected.
• •The criteria for unresectability will be: encasement or thrombosis of one or more large vessels surrounding the pancreas (celiac axis, portal vein, and/or superior mesenteric artery and/or vein, and/or hepatic artery, except the splenic vessels); infiltration of the vessel wall or contact 180° for more than 2 cm length, with initial stricture of the vessel or alteration of the Doppler signal (each patient will undergo thoracic and abdominal-CT with contrast medium to check resectability and detect the absence of distant metastasis).
• •Esclusion criteria:
• •Patients with pancreatic tumors other than pancreatic adenocarcinoma (PDAC)
• •Patients with resectable, borderline resectable or metastatic PDAC