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Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics | Clinical Trials | Clareo Health

WITHDRAWNNA

Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

NCT03641768•Duke University

Summary

The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age 18 to 65
•Previously enrolled in studies of OEF/OIF veterans by the same investigators
•Free of implanted metal objects or mental shards in eyes
•Fluent in English and capable of consenting

Exclusion Criteria

•Axis I disorders other than Major Depressive Disorder or PTSD
•Current substance abuse or lifetime substance dependence (other than nicotine)
•High risk for suicide
•Claustrophobia
•Neurological disorders
•Learning disability or developmental delay
•Major medical conditions

Locations (1)

Durham VA

Durham, North Carolina, United States

Key Dates

Start Date

January 1, 2019

Primary Completion Date

January 1, 2021

Completion Date

January 1, 2021

Last Updated

October 16, 2018

Conditions

Alzheimer DementiaPosttraumatic Stress DisorderTraumatic Brain Injury

Interventions

MRI

DEVICE

PET

DEVICE

18F-Florbetapir

DEVICE

Radioligand 18F-AV-1451

DEVICE

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

NCT04521881

Traumatic Brain Injury

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RECRUITING

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

NCT07455136

Traumatic Brain Injury

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RECRUITING

Hemodynamic ABI Monitor

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 16, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

Inclusion Criteria

Exclusion Criteria

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Hemodynamic ABI Monitor

Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD