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Acute Exposure to Hypoxia in Precapillary Pulmonary Hypertension: Physiological and Clinical Effects at Rest and During Exercise
Randomized crossover Trial in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary Hypertension (CTEPH) to assess the acute response to High Altitude (2500m above sea level) on cognitive functions
Low altitude baseline measurements will be performed in Zurich (460m) including Echocardiography, Right heart catheterization, 6 Minute walk test, pulmonary function test, clinical assessment and blood gas analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). During the exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hour, the participants will perform cognitive function test . The results will be compared to low altitude in Zurich (470m).
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Respiratory Clinic, University Hospital of Zurich
Zurich, Switzerland
Start Date
July 1, 2018
Primary Completion Date
January 1, 2019
Completion Date
January 1, 2019
Last Updated
January 7, 2020
28
ACTUAL participants
Low altitude: 470m above sea level
OTHER
Säntis; 2500m above sea Level
OTHER
Lead Sponsor
University of Zurich
NCT07073820
NCT06899815
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT07462260