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COMPLETEDPHASE3

Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs

NCT03634124•Centre Hospitalier Universitaire de Nīmes

Summary

The numerical ratio between the value of the thrombin generation test performed without soluble thrombomodulin and the value of the thrombin generation test performed in the presence of soluble thrombomodulin, performed pre-surgically, could predict the risk of early venous thromboembolism after placement of total hip or knee prosthesis.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•The patient must have his consent and signed the consent form.
•The patient must affiliated or a beneficiary of a health insurance plan.
•The patient is at least 18 years old
•Patient with an indication of total hip prosthesis or total knee replacement surgery set unilateral

Exclusion Criteria

•The patient is participating in another interventional study.
•The patient is in an exclusion period determined by a previous study.
•Minor patients, people in emergency situations.
•The patient is under the protection of justice, guardianship or curatorship.
•The patient refuses to sign the consent.
•It is not possible to inform the patient.
•The patient is pregnant, parturient, or breastfeeding.
•The patient has a contraindication (or incompatible drug combination) to drug thromboprophylaxis applied according to good clinical practice and recommendations of learned societies
•Long-term anticoagulant therapy for personal thrombotic history.
•Known hemorrhagic disease.
+14 more criteria

Locations (1)

Nimes University Hospital

Nîmes, France

Key Dates

Start Date

February 21, 2019

Primary Completion Date

February 20, 2023

Completion Date

October 17, 2023

Last Updated

February 11, 2026

Enrollment

146

ACTUAL participants

Conditions

Deep Vein ThrombosisTotal Hip ProsthesisKnee Prosthesis

Interventions

Blood test

BIOLOGICAL

Doppler ultrasound

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 11, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs

Inclusion Criteria

Exclusion Criteria

Cleaner Long-tErm Assessment Registry - Venous Insights and Efficacy With eXtended Tracking

Non-invasive Venous Air Plethysmography Assessment of Venous Hemodynamics in Patients Suspected Deep Venous Obstruction Used in Conjunction With Intermittent Pneumatic Compression.

Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery

Exclusion of Venous Thrombo-Embolism With a New Clinical Decision Support

Rheolytic Thrombectomy For Acute Deep Vein Thrombosis Of Whole Lower Limb

GEKO Venous Thromboembolism Prevention Study