Nutritional Outcomes After Vitamin A Supplementation in Subjects With SCD

Exclusion Criteria

• •Hydroxyurea initiated within the previous 6 weeks (subjects with sickle cell disease only)
• •History of stroke (subjects with sickle cell disease only)
• •Other chronic conditions that may affect growth, dietary intake or nutritional status
• •Retinoic acid (topical or oral), weight loss medication and/or lipid lowering medications
• •Subjects with a BMI greater than 98th percentile for age and sex
• •Pregnant or lactating females (subjects who become pregnant during the course of the study will not continue participation)
• •Liver function tests \>4 x upper limit of reference range
• •Participation in another study with impact on vitamin A status (subjects with sickle cell disease only)
• •Use of multi-vitamin or commercial nutritional supplements containing vitamin A (those who are willing to discontinue these supplements, with the approval of the medical care team, will be eligible for the study after a 1 month washout period. Subjects taking nutritional products without vitamin A will be eligible)
• •Inability to swallow pills (subjects with sickle cell disease only)