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Clareo Health | RANKL Inhibition and Breast Tissue Biomarkers

RANKL Inhibition and Breast Tissue Biomarkers

NCT03629717·1 site·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Lead

Washington University School of Medicine

Age

35–any

Sex

FEMALE

Healthy volunteers

Not accepted

You may be eligible if

Female.
Premenopausal.
At least 35 years of age.
Dense breasts on routine mammogram.
Willing to take calcium (1,200mg) and vitamin D (800 IU) daily.
At increased risk for breast cancer using any of the following:
* Positive family history of breast cancer
* Breast cancer risk prediction models
Able and willing to return for repeat biopsy.
Able to understand and willing to sign an IRB-approved written informed consent document.

You may not be if

Current use of tamoxifen, aromatase inhibitors, or bisphosphonates.
Concurrently participating in another cancer chemoprevention trial (unless no longer receiving the intervention).
Pregnant or lactating.
Recent tooth extraction or dental procedure.
Unhealed and/or planned dental/oral surgery.
History of osteonecrosis/osteomyelitis of the jaw.
History of osteoporosis or severe osteopenia.
Unable/unwilling to return for repeat biopsy.

The record

StatusCompleted

PhaseEarly phase 1

Taking part10

StartedJun 2018

UpdatedOct 16, 2024

Conditions

Breast Cancer Prevention Mammographic Density

Where1

Washington University School of Medicine
St Louis, Missouri, United States