Neurodevelopment of Infants Exposed to General Anesthesia: a Multi-center Investigation

Exclusion Criteria

• •Postmenstrual age ≤ 44 weeks, or postmenstrual age ≥ 144 weeks
• •Severe cardiac, pulmonary, or neurologic disease
• •Severe obstructive sleep apnea hypopnea syndrome
• •History of dystocia and/or hypoxic ischemic encephalopathy
• •Gestational age at birth ≤32 weeks
• •Any known or suspected chromosomal abnormalities, abnormal development of vision or hearing, neurodevelopment retardation, or other known acquired or congenital abnormalities that might affect neurodevelopment
• •Significant cardiovascular surgery, significant ENT surgery, or neurosurgery
• •Malignant diseases that may reduce survival
• •Taking part in other clinical trials in the last 3 months or at present