Daily vs. Non-Daily SBRT for NSCLC

Inclusion Criteria

• •≥ 18 years of age (no upper age limit).
• •A diagnosis of non-small cell lung cancer, T1-2 N0 M0 either with histologic confirmation or with documented interval growth of the index lesion on two interval computed tomography (CT) chest scans and an SUVmax of the lesion ≥ 3.0 on a pretreatment PET scan.
• •Patient must be deemed medically inoperable or refuse surgery.
• •Radiographic evaluation of the mediastinum and distant sites with a CT scan of the chest and PET scan.
• •For T2b N0 patients, radiographic evaluation of the brain with magnetic resonance imaging (MRI) of the brain unless the patient has contraindications to an MRI scan (in which case a CT scan of the head is necessary).
• •For central T1 N0 and all T2 N0 patients, pathologic sampling (either via endobronchial ultrasound-guided biopsy \[EBUS\] or mediastinoscopy) of mediastinal lymph nodes is required.
• •ECOG Performance Status 0-2.
• •For women of childbearing potential, negative pregnancy test within 2 weeks prior to SBRT treatment.
• •Patients must be deemed able to comply with the treatment plan and follow-up schedule.
• •Patients must provide specific informed consent prior to study entry.
• •Women of childbearing potential and male participants who are sexually active must use adequate contraception during treatment and for 6 weeks following treatment.