A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock

Exclusion Criteria

• •1. Patients who are ≤ 2 years (24 months) of age or ≥ 18 years of age at enrolment.
• •2. Patients with a standing Do Not Resuscitate order.
• •3. Patients diagnosed with acute occlusive coronary syndrome requiring pending intervention.
• •4. Patients on veno-arterial (VA) extracorporeal membrane oxygenation (ECMO).
• •5. Patients who have been on veno-venous (VV) ECMO for less than 6 hours.
• •6. Patients with a clinical suspicion of cardiogenic shock based on echocardiogram.
• •7. Patients who have a history of asthma or are currently experiencing bronchospasm requiring the use of inhaled bronchodilators and who are not mechanically ventilated.
• •8. Patients with acute mesenteric ischaemia or a history of mesenteric ischaemia.
• •9. Patients with active bleeding AND an anticipated need of multiple transfusions (within 48 hours of Screening).
• •10. Patients with active bleeding AND haemoglobin \< 7 g/dL.
• •11. Patients with an expected lifespan of \< 12 hours or expected withdrawal of life support within 24 hours of Screening.
• •12. Patients with a known allergy to mannitol.
• •13. Patients who are currently participating in another clinical trial using an investigational drug not approved in that member country unless specifically approved by the Sponsor.
• •14. Patients of childbearing potential who are known to be pregnant at the time of Screening.