Treatment of Spinal Cord Injury Patients for Neurogenic Bladder: Anticholinergic Agent vs. Mirabegron

Exclusion Criteria

• •1. Diagnosis of dementia or cognitive impairment from another condition such as TBI (traumatic brain injury), ALZ (alzheimers), Lewy body dementia or vascular dementia
• •2. End stage renal disease (GFR \<30) or bladder obstruction
• •3. Poorly controlled blood pressure (BP), systolic BP\>180, diastolic BP\>110 mmHg)
• •4. Renal function - exclude if serum creatinine \>2x normal range
• •5. Liver function - exclude if \>2x normal liver enzyme levels
• •6. History of, or currently active treatment for cardiac dysrhythmias, including atrial fibrillation (eg. apixaban. If subject is currently taking metoprolol they will be monitored and dose may need to be adjusted on mirabegron)
• •7. Current treatment with desipramine, digoxin
• •8. Active/unstable conditions: inflammatory, thyroid, autoimmune, gastrointestinal (GI), hematologic, or neoplastic disorders. Exclude subjects with clinical lab values outside the normal range (other than as specified above).
• •9. Subject is considered unsuitable for the study in the opinion of the investigator for any other reason