The January Application NUtritional Study (JANUS)

Exclusion Criteria

• •Smokers
• •BMI =/\> 40
• •Actively losing weight
• •Unstable diet (defined as having made any major changes to usual diet such as eliminating or significantly increasing a major food group)
• •Use of the following medications:
• •* Blood thinners (i.e. warfarin/Coumadin, clopidogrel/Plavix)
• •* Daily oral corticosteroids
• •* Hypoglycemic medication (i.e. Precose, Metformin, Avandia, Victoza)
• •* Weight loss medication
• •* Digoxin/Lanoxin
• •* Lithium/Lithobid
• •* Theophylline/Theo 24
• •Use of the following supplements, unless they agree to discontinue starting 30 days prior to the trial: any nutritional supplements containing antioxidants (examples: multi-vitamins, antioxidant combinations, or any supplement containing vitamin C, vitamin E, beta-carotene or other carotenoids, or selenium), and fish oil/cod liver oil, flaxseed oil, and supplements containing Conjugated linoleic acid (CLA)/Gamma-linolenic acid (GLA) or turmeric.
• •Use of antibiotics, antifungals/antiparasitics in the last 30 days
• •Use of probiotic or prebiotic supplements in the last 30 days
• •People allergic to: adhesives and/or prebiotics used in the trial
• •Pregnant, lactating, have given birth in the past 6 months, or are planning to get pregnant in the next 4 months
• •Self-reported health conditions:
• •* Diabetes (T1D or T2D)
• •* Inflammatory Bowel Disease (Crohn's, Ulcerative Colitis)
• •* Gastroenteritis, colitis or gastritis
• •* Active, uncontrolled Clostridium difficile infection or H. pylori (untreated)
• •* Recent heart attack (past 6 months), history of arrhythmias or cerebrovascular disease
• •* Undergoing treatment for, or underwent treatment for cancer in the past 6 months
• •* Esophageal, stomach colon or pancreatic cancer
• •* Liver disease, other than fatty liver disease
• •* Immunosuppression or immunodeficiency
• •* Positive test for HIV, Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV)
• •* Musculoskeletal disorder that would preclude you from performing moderate physical activity
• •* LDL cholesterol =/\> 190 mg/dL
• •* Triglycerides (TG) =/\> 450 mg/dL
• •* Adrenalectomy
• •* Pituitary tumor
• •* Hypothalamic disease
• •* Stage 3 kidney disease or worse
• •* Celiac disease confirmed by blood test or biopsy
• •* Insulinoma
• •* Cushing's disease
• •* Hyperthyroidism
• •* Acromegaly
• •* Pheochromocytoma
• •* Addison's disease
• •* Galactosemia
• •* Glycogen storage disease
• •* Hereditary fructose intolerance
• •* Psychotic disorders or bipolar disorders
• •* Current eating disorder
• •History of bariatric surgery, gallbladder removal, small bowel resection, or extensive bowel resection
• •Hospitalization for depression in past 6 months
• •Self-reported alcohol or substance abuse within the past 12 months
• •Current consumption of more than 14 alcoholic drinks per week, and/or current acute treatment or rehabilitation program for these problems
• •Self-reported inability to walk two blocks
• •Restrictive diets (i.e. vegetarians, vegans, or very restrictive diets, i.e. Paleo, Atkins, Ornish or ketogenic diets)
• •Planned travel (outside of weekends) over the course of the study (77 days) (weekend travel is ok)