Patients with or without isolated nocturnal hypertension will be enrolled in this study, and the patients with isolated nocturnal hypertension will be randomly divided into two groups and treated with bedtime or awakening doses of potassium losartan. Any patients who had any antihypertension medication at bedtime would withdrawal the drugs for 2 weeks before ABPM. Patients with isolated nocturnal hypertension will be randomly divided into two groups and received a bedtime or awakening dose of potassium losartan.
Age
14–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
daytime BP \<135/85mmHg，nighttime BP≥120/70mmHg；；
presence of CKD;
estimated GFR (eGFR)\<90 mL⁄ min ⁄ 1.73 m2 (using the Modification of Diet in Renal Disease Study equation) but \>30 mL⁄ min ⁄1.73 m2;
signed informed consent from participating patients.
You may not be if
pregnancy;
tumor;
infection;
renal replacement;
history of drug or alcohol abuse;
night- or shift-work employment;
treatment with steroids or hormonal therapy;
acute changes in eGFR \>30% in the past 3 months;
presence of acquired immunodeficiency syndrome;
CV disorders (unstable angina pectoris, heart failure, life-threatening arrhythmia, atrial fibrillation, kidney failure,and grade III or IV retinopathy);
intolerance to ambulatory BP monitoring (ABPM);
inability to communicate and comply with all of the study requirements.
