Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Lakefront Biotherapeutics NV
With
Institut de Recherches Internationales Servier
Age
40–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male participants or female participants of non-childbearing potential and not breastfeeding.
Body weight \> 40 kg, body mass index (BMI) \< 40 kg/m\^2.
Diagnosed for knee osteoarthritis based on clinical and radiological criteria of the American College of Rheumatology.
History of knee pain for at least 6 months and on the majority of days (\> 50%) during the preceding month.
Symptom severity defined by a pain ≥ 40 mm and ≤ 90 mm on visual analogue scale (VAS, 100 mm) at screening and inclusion visits.
Documented need for symptomatic as needed-treatment for osteoarthritis (OA) in the target knee with systemic non-steroidal anti-inflammatory drugs (NSAIDs) and/or other analgesics
You may not be if
Severe clinical knee malalignment according to the investigator.
Knee prosthesis already implanted (\< 1 year) or not well-tolerated (contralateral side).
Knee prosthesis already foreseen within the study period (whichever side).
Hip prosthesis recently implanted (\< 1 year) or foreseen within the study period (whichever side).
Previous osteotomy on the inferior limbs (whichever side).
Surgical operation on the target knee within the 12 months prior to the screening visit or planned during the study.
Diagnostic arthroscopy of the target knee within the 6 months prior to the screening visit or planned during the study.
Other pathologies affecting the target knee.
Any contraindication to magnetic resonance imaging (MRI) including the inability to undergo a knee MRI exam because of inability to fit in the scanner or knee coil.
Clareo Health | A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Participants With Knee Osteoarthritis
