Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Washington University School of Medicine
With
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Restricting sleep is known to be detrimental to glucose metabolism in healthy adults. Obesity is a condition associated with both lower sleep duration and poor glucose tolerance. Therefore, increasing sleep duration is a potentially novel therapeutic strategy for improving glucose metabolism in this population. The investigators will assess this by determining insulin sensitivity during a hyperinsulinemic-euglycemic clamp before and after a sleep intervention in both the control and sleep extension groups.
Age
21–65
Sex
FEMALE
Healthy volunteers
Accepted
You may be eligible if
Sleep \<7h/night
Body mass index 25-50 kg/m2
Altered glucose metabolism (any of the following) Fasting glucose 100-125 mg/dL or, 2-h plasma glucose 140-199 mg/dL during an oral glucose tolerance test (OGTT) or, HbA1c 5.7-6.4% or, homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.0
You may not be if
Sleep disorders
1. moderate to severe sleep apnea (apnea-hypopnea index ≥15 events/hour)
2. had ≥15 periodic limb movements per hour sleep \[PLMS\]
3. narcolepsy or insomnia
Perform shift work
Excessive caffeine or alcohol consumption
Significant organ dysfunction/disease (e.g. diabetes mellitus, kidney disease)
Liver disease other than metabolic dysfunction associated steatotic liver disease (MASLD)
Prior bariatric surgery
Pregnancy or breastfeeding
Taking medications that can affect study outcomes (alter sleep duration or glucose metabolism)
Tobacco or illicit drug use
Perform intense exercise \>70 min/wk or moderate exercise \>150 min/week
Excessive alcohol consumption (\>21 units of alcohol per week for men and \>14 units of alcohol per week for women)
Clareo Health | Metabolic Effects of Sleep Extension in People With Obesity
