Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers

Exclusion Criteria

• •Clinically significant abnormality on screening ECG.
• •Sustained blood pressure recordings at screening of \< 90 mmHg or \> 150 mmHg for systolic blood pressure, or \< 50 mmHg or \> 90 mmHg for diastolic blood pressure.
• •Sustained resting heart rate of \> 100 or \< 40 beats per minute at screening.
• •Positive result for urine drugs of abuse test or alcohol breath test at screening.
• •Clinically significant abnormality in laboratory test results at screening, in the opinion of the Investigator.
• •Positive urine pregnancy test at screening or Assessment Days in female subjects of child bearing potential.
• •Any clinically significant concomitant disease or conditions.