A Study to Evaluate How Aprocitentan is Safe and How it is Absorbed and Broken Down in the Body of Japanese and Caucasian Subjects

Inclusion Criteria

• •Subjects must be of Caucasian or Japanese ethnicity
• •Signed informed consent in a language understandable to the subject prior to any study-mandated procedure
• •Body mass index (BMI) of 18.0 to 28.0 kg/m2 (inclusive) at Screening
• •Systolic blood pressure 100-145 mmHg, diastolic blood pressure 50-90 mmHg, and pulse rate 45-90 bpm (inclusive), measured on the same arm, after 5 min in the supine position at Screening
• •A woman of childbearing potential is eligible only if the following applies:
• •Negative serum pregnancy test at Screening,
• •Negative urine pregnancy test on Day -1,
• •Agreement to consistently and correctly use a reliable method of contraception from Screening up to at least 30 days after last study treatment administration
• •Japanese subjects only
• •Subjects must be of native Japanese descent (all parents/grandparents of Japanese descent).
• •Subjects must not have been away from Japan for more than 10 years (at Screening visit).
• •Subject's lifestyle should not have changed significantly since relocation from Japan