Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children

You may be eligible if

• Obsessive-Compulsive Disorder (OCD) patient group
• INCLUSION:
• 1. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Diagnosis of OCD as the principal problem
• 2. Not on psychotropic medication and not receiving current psychotherapy for OCD
• 3. Written informed assent by the participants and consent by the parent
• 4. Participants and a parent/guardian must be able to read and understand English
• EXCLUSION
• 1. DSM-5 current diagnosis of major depressive disorder, or substance/alcohol abuse
• 2. DSM-5 lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, or substance/alcohol abuse
• 3. Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications (stable doses of stimulants or other types of ADHD medications - e.g. Guanfacine - are allowable for OCD subjects with comorbid attention deficit hyperactivity disorder following investigator review of medication; on day of study scan, subjects must be willing to refrain from taking medication until after scan is completed)
• 4. Active suicidal ideation
• 5. Females who are pregnant or nursing
• 6. Major medical or neurological problems
• 7. Presence of metallic device or dental braces
• 8. Intelligence Quotient (IQ)\<80
• 9. A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• 10. Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications
• 11. Individuals who have received a full course of CBT in the past
• 12. A positive pregnancy test
• 13. Positive urine screen for illicit drugs
• Healthy controls
• INCLUSION:
• 1. Written informed assent by the participants and consent by the parent
• 2. Participants and a parent/guardian must be able to read and understand English
• EXCLUSION:
• 1. Any current or lifetime psychiatric diagnosis
• 2. Active suicidal ideation
• 3. Females who are pregnant or nursing
• 4. Major medical or neurological problems
• 5. Presence of metallic device or dental braces
• 6. IQ \<80
• 7. A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• 8. A positive pregnancy test
• 9. Positive urine screen for illicit drugs
• Obsessive Compulsive Symptoms
• INCLUSION:
• 1. Presence of obsession(s) and/or compulsion(s) but no current diagnosis of OCD (i.e.,\<1 hour/day, no more than mild interference or distress)
• 2. Not on psychotropic medication and not receiving current psychotherapy for OCD
• 3. Written informed assent by the participants and consent by the parent
• 4. Participants and a parent/guardian must be able to read and understand English
• EXCLUSION:
• 1. DSM-5 current diagnosis of major depressive disorder, attention-deficit hyperactivity disorder, Tourette's/Tic Disorder, or substance/alcohol abuse
• 2. DSM-5 lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, or substance/alcohol abuse
• 3. Active suicidal ideation
• 4. Females who are pregnant or nursing
• 5. Major medical or neurological problems
• 6. Presence of metallic device or dental braces
• 7. IQ\<80
• 8. A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• 9. Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications
• 10. Individuals who have received a full course of CBT in the past
• 11. Positive urine screen for illicit drugs