Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

You may be eligible if

• Diagnosis of malignant disease of any stage; (stage I through stage IV)
• No prior history of chemotherapy for any malignancy
• Scheduled to receive intravenous HEC (highly emetogenic chemotherapy) (either cisplatin-containing regimen or doxorubicin and cyclophosphamide \[AC\]); cisplatin, given on a single day, at a dose of \>= 70 mg/m\^2, with or without other chemotherapy agent(s) OR doxorubicin (60 mg/m\^2) plus cyclophosphamide (600 mg/m\^2)
• No nausea or vomiting =\< 24 hours prior to registration
• Negative pregnancy test (serum or urine) done =\< 7 days prior to registration, for women of childbearing potential only
• \* A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
• No known diagnosis of dementia; patients with stable treated brain metastases are eligible to participate
• No known history of central nervous system (CNS) disease (e.g. seizure disorder)
• No treatment with another antipsychotic agent such as olanzapine, risperidone, quetiapine, clozapine, phenothiazine or butyrophenone =\< 30 days prior to registration
• No chronic phenothiazine administration as an antipsychotic agent (patients may receive prochlorperazine and other phenothiazines as rescue anti-emetic therapy but not within 24 hours prior to registration)
• No use of amifostine within 7 days prior to registration
• No radiotherapy within 7 days prior to registration or planned for one week after the current dose of chemotherapy
• No use of quinolone antibiotic therapy within 7 days prior to registration
• No chronic alcoholism (as determined by the investigator)
• No known hypersensitivity to olanzapine
• No known uncontrolled cardiac arrhythmia, no known uncontrolled congestive heart failure, or no acute myocardial infarction within the previous six months
• Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2
• Patients must be able to read and comprehend English; local translation, including verbal translation of patient-reported outcomes (PROs) is not permitted
• Serum creatinine =\< 2.0 mg/dL =\< 120 days prior to registration
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =\< 3 x upper limit of normal (ULN) =\< 120 days prior to registration