Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Patient has no clinically significant findings on a physical examination and clinical laboratory tests
Female patients of childbearing potential must agree to use one of the following methods of birth control:
1. Hormonal contraception
2. Double-barrier birth control
3. Maintenance of a monogamous relationship with a male partner who has been surgically sterilized by vasectomy
Patient meets protocol criteria for diagnosis of IBS-C
Patient demonstrates continued IBS-C symptoms through Pretreatment Period
Patient maintains a minimum level of compliance with daily diary

Patient has history of loose or watery stools
Patient has symptoms of or been diagnosed with a medical condition that may contribute to abdominal pain
Patient has a structural abnormality of the gastrointestinal (GI) tract or a disease or condition that can affect GI motility
Patient has any protocol-excluded or clinically significant medical or surgical history that could confound the study assessments

A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)