Finding studies
Finding studies
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Lead
University of Washington
With
PRIMARY OBJECTIVE: I. To assess the pathological complete response rate following olaparib when administered as neoadjuvant therapy prior to prostatectomy in patients with localized prostate cancer containing homozygous or complementary deoxyribonucleic acid \[DNA\] repair deficiency. SECONDARY OBJECTIVE: I. To determine the rate of positive surgical margins, extracapsular extension, positive seminal vesicles and lymph nodes at the time of prostatectomy. OUTLINE: Participants receive olaparib orally twice daily for 90 days in the absence of unacceptable toxicity. Beginning 1 day after last olaparib dose, participants undergo radical prostatectomy. After completion of study treatment, participants are followed up for 30 days.
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted