MTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma

Inclusion Criteria

• •Patients who have completed focal radiotherapy within 14 weeks from time of enrollment are eligible.
• •Treatment must begin at a minimum of 4 weeks after, but no later than 14 weeks after, the date of completion of focal radiotherapy.
• •Prior chemotherapy: Patients should be at least 30 days from last chemotherapy dose prior to start of CED infusion, with exception of antibody half-lives. For antibody therapies, at least 3 half-lives of the antibody after last dose of monoclonal antibody should have passed prior to CED infusion. Patients less than 30 days from last chemotherapy dose should be discussed with the study chair(s).
• •Prior radiation: Patients must have received prior treatment with focal radiotherapy as part of initial treatment for DIPG and had their last dose at least 4 weeks prior to and no later than 14 weeks from the first CED treatment. Standard focal radiation therapy will include 54 to 60 Gy by external beam radiotherapy to the brainstem.
• •Age ≥ 2 years of age to 21 years. Patients younger than 3 years of age may be enrolled on study at the discretion of the Study Chair(s) if supporting evidence that brainstem lesion represents a brainstem glioma.
• •Karnofsky Performance Score ≥ 50 for patients \> 16 years of age and Lansky Performance Score ≥ 50 for patients ≤ 16 years of age. Patients who are unable to walk because of paralysis, but who are able to mobilize using a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.
• •Life expectancy of greater than 12 weeks measured from the date of completion of radiotherapy.
• •Corticosteroids: Patients who are receiving dexamethasone must be on a stable or decreasing dose for at least 1 week prior to registration.
• •Peripheral absolute neutrophil count (ANC) ≥ 1000/mm\^3.
• •Hemoglobin ≥ 8g/dl.
• •Platelet count ≥ 100,000/mm\^3 (transfusion independent, defined as not receiving platelet transfusions for at least 7 days prior to enrollment).
• •Normal coagulation defined as normal International Normalized Ratio (INR) or per institutional guidelines.
• •Creatinine clearance or radioisotope glomerular filtration rate (GFR) ≥ 70 milliliters (mL)/minute (min)/1.73 m\^2.
• •A serum creatinine (mg/dL) based on age/gender as follows:
• •* Age: 2 to \< 6 years; Male: 0.8; Female: 0.8
• •* Age: 6 to \< 10 years; Male: 1; Female: 1
• •* Age: 10 to \< 13 years; Male: 1.2; Female: 1.2
• •* Age: 13 to \< 16 years; Male:1.5; Female: 1.4
• •* Age ≥ 16 years; Male: 1.7; Female: 1.4
• •Bilirubin (sum of conjugated + unconjugated) ≤ 1.5 x upper limit of normal (ULN) for age.
• •Serum glutamate pyruvate transaminase (SGPT) \[alanine aminotransferase (ALT)\] ≤ 110 U/L.
• •Serum albumin ≥ 2 g/dL.
• •Patients with seizure disorder may be enrolled if on non-enzyme inducing anticonvulsants and well controlled.
• •The effects of MTX110 on the developing human fetus are unknown. For this reason women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and 4 months after completion of MTX110 injection administration. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
• •Able to understand, and willing to sign, a written informed consent document.
• •Patients who are unable to return for follow-up visits or obtain follow-up studies required to assess toxicity to therapy.