Safety Study of S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine in Healthy Volunteers Aged Above 3 Months

Exclusion Criteria

• •Febrile illness (temperature ≥ 38°C) in the 3 days.
• •Subject who are allergic to tetanus toxoid.
• •Allergic history after vaccination.
• •Immunodeficiency diseases patients who administered with immunosuppressive agents.
• •In pregnancy or lactation or pregnant women.
• •Subject who are suffering from serious chronic diseases, infectious diseases, active infection, cardiovascular disease,liver or kidney disease.
• •Subject who have symptoms such as diarrhea, abdominal pain, and pus and bloody stools in the past 3 days.
• •History of allergy，eclampsia, epilepsy,brain trauma,encephalopathy and mental disease or family disease.
• •Subject who diagnosis of thrombocytopenia or other history of coagulopathy may cause intramuscular contraindication.
• •Children with abnormal labor（pregnancy week\<37w,\>42w）,birth weight (\<2500g,\>4000g), asphyxia rescue history,congenital malformations or developmental disorders(Only applicable to 3-5 months old group)
• •Blood routine, blood chemistry and urinalysis laboratory collection abnormalities and the severity of grade 2 and above before immunization.
• •Subject who plan to participate in or is in any other drug clinical trial.
• •Any condition that, in the judgment of investigator, may affect trial assessment.