Mediterranean Diet, Circuit Resistance Training, Empagliflozin in Elderly With Type 2 Diabetes: a Study Protocol

Exclusion Criteria

• •1. Recent use of steroid agents (\<6 months, replacement therapy is allowed)
• •2. Uncorrected hypothyroidism \[thyroid stimulating hormone (TSH) \> 6 mlU/L\]
• •3. Diagnosis of malignancy within the past 5 years except for non-melanoma skin cancer.
• •4. Severe kidney disease (eGFR\<45cc/ml)
• •5. Active depression
• •6. Recent (≤6 months) or unstable cardiovascular condition; New York Heart Association (NYHA) Class 3 or higher congestive heart failure;
• •7. Subjects with PA limiting pain due to neuropathy
• •8. Subjects who are in an active nutritional therapy changed their diet recently (\<1 month) and/or in a weight-loss program (actively losing weight).
• •9. Has other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results.