Dupilumab As An Adjunct For Subcutaneous Grass Immunotherapy

Exclusion Criteria

• •1. Significant rhinitis, sinusitis, outside of the grass pollen season
• •2. Any contraindications to SCIT (i.e, severe cardiovascular disease, malignancies, autoimmune disease, use of beta blocker, asthma severe enough to require chronic medication, acute infection)
• •3. Use of systemic corticosteroids within 4 weeks of screening visits or any NAC visits
• •4. Abnormal lung function as judged by the investigator
• •5. A clinical history of asthma requiring chronic medication such as regular inhaled corticosteroids for \>4 weeks per year
• •6. History of significant recurrent sinusitis, defined as 3 episodes per year for the last 2 years, all of which required antibiotic treatment
• •7. History of chronic sinusitis (with or without nasal polyps)
• •8. Tobacco smoking (ANY) within the last year