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EEG Studies of Ketamine General Anesthesia | Clinical Trials | Clareo Health

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COMPLETEDPhase 2/3NCT03553758

EEG Studies of Ketamine General Anesthesia

We are doing this research study to find out how and where ketamine acts in the brain. Ketamine is an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain by putting you in an...

Lead sponsor: Massachusetts General Hospital•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Massachusetts General Hospital

In this trial, participants will be given ketamine at a high enough dosage to induce general anesthesia. EEG recording will be conducted during this time. Cognitive assessments and pain monitoring will be administered at various points before and after ketamine induction.

Age

18 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Between the ages of 18 to 45
•Normal body weight and habitus, BMI less than or equal to 30
•Non-smoker
•American Society of Anesthesiologists (ASA) physical status classification P1

Exclusion Criteria

•Cardiovascular: myocardial infarction, coronary artery disease, peripheral vascular disease, arrhythmia, congestive heart failure, valvular disease, hypertension
•Respiratory: bronchitis, chronic obstructive pulmonary disease, smoking, shortness of breath
•Hepatic: hepatitis, jaundice, ascites
•Neurologic: seizure, stroke, positive neurologic findings on neurologic examination, multiple sclerosis, Meniere's disease, Parkinson's disease, neuropathy, peripheral stenosis
•Gastrointestinal: esophageal reflux, hiatal hernia, ulcer
•Endocrine: diabetes, thyroid disease
•Renal: acute or chronic severe renal insufficiency
•Hematologic: blood dyscrasias, anemia, coagulopathies, on anticoagulant therapy
•Musculoskeletal: prior surgery or trauma to head neck or face, arthritis, personal or family history of malignant hyperthermia
•Psychiatric: history or treatment for an active psychiatric problem, depression
•Reproductive: pregnancy, breast-feeding
•Medications: regular use of prescription and non-prescription medications expected to affect CNS function, St. John's Wort
•Allergies: labetalol, ondansetron, glycopyrrolate, ketamine, midazolam

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 26, 2020Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2/PHASE3

Enrollment16

Start dateNov 2018

Last updatedAug 26, 2020

Condition

Locations shown

Massachusetts General Hospital

Boston, Massachusetts

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 26, 2020Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions