Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Alberta
With
Canadian Institutes of Health Research (CIHR)
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Resting SBP \>120 mmHg systolic on screening BP clinic measurements (with an electronic sphygmomanometer, mean of three readings after first reading is discarded) and at least one previous SBP measurement above 120 mmHg on a separate occasion within the past six months (home or clinic measurement).
Stable on blood pressure medications for the past eight weeks
eGFR 15-44 ml/min per 1.73m2 eGFR between 15-44 ml/min per 1.73m2 within the last three months and one additional value in this rage in the last 12 months.
Independent ambulation with or without an assistive device for at least three consecutive minutes
Cognition and English language sufficient enough to understand written information, provide consent, and comply with the testing and interventions
Approval of the attending nephrologist
No significant exercise-induced arrhythmia or new ischemia on submaximal incremental exercise testing (final screening step)
You may not be if
Resting SBP \>160 mmHg or DBP \> 110 mmHg on screening BP clinic measurement (Note: the individual may be re-screened 8 weeks after medication adjustment)
Arm circumference greater than 54 centimeters (size limit of large ABPM cuff)
Recent (\<6 weeks) or planned (\<6 months) major cardiovascular events or procedures
Any known contraindication to exercise (American College of Sports Medicine Guidelines)
Acute myocardial infarction (3-5 days) or unstable angina; Uncontrolled symptomatic arrhythmias; Active endocarditis; Acute myocarditis or pericarditis; Symptomatic severe aortic stenosis; Acute pulmonary embolism or deep vein thrombosis; Suspected dissecting aneurysm; Uncontrolled asthma; Uncontrolled pulmonary edema; Room air desaturation to \<85%; Acute non-cardiopulmonary disorder that may affect exercise performance (infection, orthopedic problem); Mental impairment leading to inability to cooperate; Uncontrolled hypertension (as above)
Pregnant or planning to become pregnant
Transplant
Life expectancy or predicted time to renal replacement therapy \<9 months (attending physician judgment)
Planned move or hospital admission within the next 9 months
Currently enrolled in an interventional clinical trial; currently enrolled in a structured exercise program or performing regular exercise training \> 2 day/week in the last 3 months
Taking other medications known to affect blood pressure (prednisone cyclosporine) and expected adjustment in the next 9 months
Significant barrier to participation in a home exercise program or an insurmountable barrier to attend in-center training sessions.
Clareo Health | Physical Activity in Renal Disease (PAIRED): The Effect on Hypertension
