Effects of Physical Training on Vascular Function as a Therapeutic Target in Pulmonary Hypertension

Inclusion Criteria

• •Age over 18 years
• •Functional class of New York Heart Association (NYHA) II-III
• •Diagnosis of pulmonary hypertension (PH) by right heart catheterization, as follows:
• •Mean pulmonary arterial pressure (mPAP) \>=25 mmHg
• •Pulmonary vascular resistance (PVR) ≥240 din / s / cm5
• •Pulmonary interlock pressure (PCWP) ≤15 mmHg
• •Patients with optimized PAH treatment, including intensified treatment with diuretics and who have remained stable for at least 2 months before entering the study (changes in medical treatment are not expected during the entire 12-week study period)
• •Be able to understand and be willing to sign the informed consent form