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Keep this study
Lead
Bayer
With
Merck Sharp & Dohme LLC
Canadian VIGOUR Centre
Duke Clinical Research Institute
Age
45–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Previous diagnosis of chronic heart failure (HF)
HF decompensation within 6 months prior to randomization, defined as hospitalization for HF or intravenous (IV) diuretic treatment for HF without hospitalization.
N-terminal pro brain natriuretic peptide (NT-proBNP) ≥300 or brain natriuretic peptide (BNP) ≥100 pg/mL in sinus rhythm, or NT-proBNP
≥600 or BNP ≥200 pg/mL in atrial fibrillation within 30 days prior to randomization
Diagnostic criteria of HFpEF by echocardiography assessed within 12 months prior to randomization (most recent measurement must be used to determine eligibility with no interim event signaling potential deterioration in ejection fraction)
* Left ventricular ejection fraction (LVEF) ≥45% and
* Structural changes indicated by at least one of the following parameters:
* Left ventricle (LV) hypertrophy (any of the following: intraventricular septal or posterior wall thickness ≥1.1 cm, and/or LV mass index ≥115 g/m\*2 in male and ≥95 g/m\*2 in female), or
* Left atrium (LA) enlargement (any of the following: left atrial volume (LAV) index ≥29 ml/m\*2, or LAV \>58 mL in male and \>52 mL in female patients, or LA area \>20 cm\*2, or LA diameter \>40 mm in male and \>38 mm in female patients)
NYHA class II or III at randomization
You may not be if
Clinical instability at randomization, defined by
* Any IV treatment within 24h prior to randomization, and/or
* Resting heart rate (HR) \<50 or ≥100 beats per minute (bpm)
Use of IV inotropes at any time between qualifying HF event and randomization
Previous diagnosis of reduced ejection fraction (EF) (EF \<40%)
Hypertrophic obstructive cardiomyopathy, acute myocarditis, amyloidosis, sarcoidosis, or pericardial disease
Primary valvular heart disease requiring surgery or intervention, or within 3 months after valvular surgery or intervention, or active endocarditis
Acute coronary syndrome, including unstable angina, Non ST-elevation myocardial infarction or ST-elevation myocardial infarction, or Coronary artery bypass grafting (CABG) within 60 days prior to randomization, or indication for Percutaneous coronary intervention or CABG at the time of randomization
Symptomatic carotid stenosis, or transient ischemic attack or stroke within 60 days prior to randomization
Complex congenital heart disease
Non-cardiac comorbidity (any of the following)
* Estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73 m\*2 calculated by Modification of Diet in Renal Disease formula
* Hepatic insufficiency classified as Child-Pugh B or C
* Morbid obesity with a body mass index \>45 kg/m\*2
* Malignancy or other non-cardiac condition limiting life expectancy to \<1 year, per physician judgment
* Requires continuous home oxygen for severe pulmonary disease or has interstitial lung disease
* Patients with allergies, intolerance or hypersensitivity to investigational drug or any of the excipients
Concurrent or anticipated use of nitrates or NO donors, phosphodiesterase type V (PDE5) inhibitors, or a Soluble guanylate cyclase (sGC) stimulator
Clareo Health | Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF
