Lead Sponsor

University Hospital of Ferrara

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•primary and secondary progressive MS patients according to the diagnostic MS criteria revised by Polman et al.
•Male and females, aged 18 to 65 years;
•Severe gait impairments, defined by an Expanded Disability Status Scale (EDSS) ranging from 5.5 to 6.5;
•Lack of MS worsening in the previous three months prior to the intervention period;
•Cognitive functioning to provide informed consent identified by a Mini-Mental Status Examination (MMSE) score = 24/30.

•Neurologic conditions in addition to MS that may affect motor function and other medical conditions likely to interfere with the ability to complete safely the study protocol, independently from the group assignment;
•Considerable muscle spasticity, defined by a Modified Ashworth Scale (MAS) score \> 3 or contractures that may limit range of motion or function for hip, knee or ankle flexors/extensor;
•Relapsing of MS-related conditions or changes in drug therapy or any other confounding factor during the study;
•Rehabilitation treatments or Botulinum toxin injections during the three months preceding the start of the study.
•Intermittent claudication and peripheral artery disease
•Contraindication to exercise training (e.g., unstable angina, congestive heart failure)

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