Study of rhPro-UK in Patients With Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset(PROST)

Exclusion Criteria

• •1. Patients with premorbid modified Rankin Scale (mRS) score ≥2
• •2. CT showed multiple infarctions（low density\> 1/3 cerebral hemisphere）.
• •3. Transient ischemic attack.
• •4. Epileptic seizure after stroke.
• •5. Intracranial tumor, arteriovenous malformation and aneurysm.
• •6. Iatrogenic Stroke.
• •7. Planned for thrombectomy.
• •8. Cardioembolism and atrial fibrillation.
• •9. Myocardial infarction history within 3 months.
• •10. Severe cerebral trauma or stroke history within 3 months.
• •11. Patients with systolic blood pressure ≥ 180mmHg or diastolic blood pressure ≥ 100mmHg after anti-hypertension treatment.
• •12. Intracranial hemorrhage or subarachnoid hemorrhage on baseline.
• •13. Active visceral hemorrhage.
• •14. Patients with intracerebral hemorrhage history.
• •15. Patients with diabetic retinopathy history.
• •16. Puncture in 1 week which can not be oppressed.
• •17. Major surgery or severe trauma within 2 weeks.
• •18. Intracranial surgery, intraspinal surgery or solid organ biopsy within 30 days.
• •19. Heparin treatment within 48h and increased APTT is above ULN.
• •20. Using of oral anticoagulant drugs and PT \>15s or INR \>1.7.
• •21. High risk of acute hemorrhage include platelet count\<10\^9/L.
• •22. Using of thrombin inhibitors or factor Xa inhibitor with abnormal results of sensitive laboratory examination.
• •23. Blood glucose \< 2.7 mmol/L or \> 22.2 mmol/L.
• •24. Pregnancy, lactating or menstrual women.
• •25. The investigator believes that the patient is not suitable for the study.