Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
With
American Heart Association
Age
21–69
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Prediabetes defined by HbA1c 5.7-6.4%, or type 2 diabetes with HbA1c 6.5-6.9%
Class I-III obesity (BMI 30-50 kg/m2)
If on medications for hypertension, stable regimen for at least past 6 months
Willingness to adjust timing of feeding
Willingness and ability to eat study diet and nothing else during run-in and intervention
Willingness to complete measurement procedures
You may not be if
Moderate to severe obstructive sleep apnea
Shift work;
Other sleep/circadian disorders: e.g., circadian phase delay or phase advance; restless legs syndrome, insomnia, narcolepsy, habitual sleep \<6 hours/night
Routinely ate within compressed time window in the past year (e.g., routinely eats all food within an 10-hour or narrower window, follows an intermittent fasting protocol)
Renal dysfunction (estimated Glomerular Filtration Rate (GFR) \<30 using the simplified Chronic Kidney Disease (CKD) Epidemiology Collaboration (EPI) equation 34)
Use of glucose-lowering medications, weight loss medications, medications for sleep disorders (sedative/hypnotic drugs, stimulants), lithium, systemic corticosteroids, diuretics, blood thinners requiring regular monitoring (e.g. warfarin), anti-psychotic drugs and antiretroviral therapy
Body weight \>400 pounds (limitation of facility scales)
\>1 drink per day of alcohol
Active substance use disorder or significant psychiatric/psychologic disorder that would interfere with participation
Significant food allergies, preferences, intolerances, or dietary supplements that would interfere with diet adherence
Weight loss or gain of ≥5% during past 6 months
Pregnant, planning to become pregnant, or breastfeeding
Planning to start a weight loss program
Planning to leave the area prior to end of study
Current participation in another clinical trial
Cancer diagnosis requiring active treatment in past two years or planned treatment (with exception of localized non-melanoma skin cancer)
Active inflammatory bowel disease, malabsorption, or history of major gastrointestinal surgery involving bowel resection
Myocardial infarction or stroke in past 6 months
Prior bariatric surgery
Any serious illness that would interfere with participation
Other conditions or situations at the discretion of the PI
Clareo Health | The Time-Restricted Intake of Meals Study
