The Time-Restricted Intake of Meals Study

Exclusion Criteria

• •Moderate to severe obstructive sleep apnea
• •Shift work;
• •Other sleep/circadian disorders: e.g., circadian phase delay or phase advance; restless legs syndrome, insomnia, narcolepsy, habitual sleep \<6 hours/night
• •Routinely ate within compressed time window in the past year (e.g., routinely eats all food within an 10-hour or narrower window, follows an intermittent fasting protocol)
• •Renal dysfunction (estimated Glomerular Filtration Rate (GFR) \<30 using the simplified Chronic Kidney Disease (CKD) Epidemiology Collaboration (EPI) equation 34)
• •Use of glucose-lowering medications, weight loss medications, medications for sleep disorders (sedative/hypnotic drugs, stimulants), lithium, systemic corticosteroids, diuretics, blood thinners requiring regular monitoring (e.g. warfarin), anti-psychotic drugs and antiretroviral therapy
• •Body weight \>400 pounds (limitation of facility scales)
• •\>1 drink per day of alcohol
• •Active substance use disorder or significant psychiatric/psychologic disorder that would interfere with participation
• •Significant food allergies, preferences, intolerances, or dietary supplements that would interfere with diet adherence
• •Weight loss or gain of ≥5% during past 6 months
• •Pregnant, planning to become pregnant, or breastfeeding
• •Planning to start a weight loss program
• •Planning to leave the area prior to end of study
• •Current participation in another clinical trial
• •Cancer diagnosis requiring active treatment in past two years or planned treatment (with exception of localized non-melanoma skin cancer)
• •Active inflammatory bowel disease, malabsorption, or history of major gastrointestinal surgery involving bowel resection
• •Myocardial infarction or stroke in past 6 months
• •Prior bariatric surgery
• •Any serious illness that would interfere with participation
• •Other conditions or situations at the discretion of the PI