Acetazolamide and Exercise Performance at Altitude

Exclusion Criteria

• •Females who are pregnant or planning to become pregnant during the study
• •Taking dietary supplements, prescriptions, or over the counter medication, other than a contraceptive (unless approved by OMSO and PI)
• •Born at altitudes greater than 2,100 m (\~7,000 feet; Examples include Santa Fe, New Mexico; Laramie, Wyoming; Etc.)
• •Living in areas that are more than 1,200 m (\~4,000 feet), or have traveled to areas more than 1,200 m for five days or more within the last 2 months (Examples include Ft. Huachuca, Arizona; Lima, Peru; Feldberg, Germany; etc.)
• •Physical problems/injuries associated with walking or running on a treadmill
• •Allergy to skin adhesive
• •Abnormal blood count (For example: hemoglobin (Hb) outside of the normal ranges (Normal \[Hb\] Males = 12.6-17.7 g/dL; Females = 11.1-15.9 g/dL) or hematocrit (Hct) outside of the normal ranges (Normal Hct Males = 37.5-51.0%; Females = 34.0-46.6%) levels, presence of abnormal blood chemicals (hemoglobin S or sickle cell traits)
• •Prior HAPE (high altitude pulmonary edema) or HACE (high altitude cerebral edema) diagnosis
• •Smokers or tobacco/nicotine users (unless have quit more than 4 months prior)
• •Presence of asthma or respiratory tract infections (unless more than 1 month prior or approved by OMSO).
• •Allergy to sulfa drugs (Acetazolamide)
• •Evidence of apnea or other sleeping disorders
• •History of neurologic (e.g. stroke, seizure), speech, facial muscle disorder or injuries preventing from producing normal range of hand and finger motion
• •Experiencing colds, coughs, or sinus infections
• •Food allergies/intolerances to gluten and/or dairy
• •Low blood Na+/K+ values ( Na+: \< 135 mmol/L, K+: \<3.5 mmol/L)
• •Kidney, liver or adrenal dysfunction
• •Breastfeeding mothers