Molecular Profile of Breast Cancer in Ugandan Patients With Stage IIB-III Breast Cancer

Inclusion Criteria

• •Women with any menopausal status, with newly diagnosed, locally advanced and histologically confirmed invasive breast cancer (Patients with stage 2B \[i.e. T3N0\], 3A, 3B, and 3C disease)
• •Absolute neutrophil count (ANC) \> 1500/mm
• •Hemoglobin \> 9 g/dL
• •Platelets \>=100,000 cells/mm\^3
• •Total bilirubin =\< 1.2 mg/dL
• •International normalized ratio (INR) =\< 1.5 x upper limit of normal (ULN)
• •Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 1.5 x ULN
• •Serum alkaline phosphatase should be 1.5 x ULN
• •Patients with positive hepatitis B or C serologies without known active disease must meet the eligibility requirements for ALT, AST, total bilirubin, INR, activated partial thromboplastin time (aPTT), and alkaline phosphatase on at least two consecutive occasions, separated by at least 1 week
• •Adequate renal function with serum creatinine \< 1.5 x ULN
• •Premenopausal patients must have a negative serum or urine pregnancy test, including women who have had a tubal ligation and for women less than 12 months after the onset of menopause
• •Women of childbearing potential must be willing to use one highly effective form of nonhormonal contraception or two effective forms of nonhormonal contraception by the patient and/or partner and continue its use for the duration of the study treatment
• •Left ventricular ejection fraction \>= 50%
• •Eastern Cooperative Oncology Group (ECOG) performance status \< 2
• •Signed written informed consent