HIPEC After Radical Cystectomy for High Risk Bladder Cancer

Exclusion Criteria

• •1. Subjects who have previously undergone intraperitoneal chemotherapy.
• •2. Subjects with tumor histology other than urothelial cell carcinoma.
• •3. Patients on concurrent anti-cancer therapy other than that allowed in the study.
• •4. Other prior malignancies, except for cured non-melanoma skin cancer or curatively treated in situ carcinoma of the cervix or adequately treated malignancies for which there has been no evidence of activity for more than 3 years.
• •5. Subjects with renal insufficiency defined as creatinine \> 1.5x the upper limit of normal or a calculated creatinine clearance of \< 50 cc/min.
• •6. Subjects with a condition which may interfere with the subjects' ability to understand the requirements of the study.
• •7. Known HIV, Hepatitis B or Hepatitis C positive.
• •8. Subjects with uncontrolled concurrent illness including, but not limited to, ongoing or severe infection requiring antibiotics, symptomatic congestive heart failure, unstable angina pectoris, acute gastrointestinal bleeding, psychiatric illness or other condition which in the opinion of the investigator, places the patient at an unacceptable risk for participation in the study.
• •9. Any condition that would preclude the ability to deliver appropriate IP therapy.