Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

Exclusion Criteria

• •1. Diagnosis or co-diagnosis of extra pulmonary TB.
• •2. Hospitalized for the current episode of drug susceptible pulmonary TB disease.
• •3. History of or ongoing severe disease that in the opinion of the investigator might affect the safety of the participant or the immunogenicity of the investigational product.
• •4. Insulin dependent diabetes.
• •5. History of allergic disease or reactions likely to be exacerbated by any component of the investigational product.
• •6. History or laboratory evidence of immunodeficiency, autoimmune disease or immunosuppression.
• •7. History of chronic hepatitis.
• •8. Severe anemia, defined as hemoglobin less than 10 g/dL or a hematocrit less than 30% based on most recent hematology obtained before randomization.
• •9. History of receipt of treatment against active TB, prior to the current treatment episode, within the last 5 years
• •10. Receipt of any investigational TB vaccine previously.
• •11. Receipt or planned receipt of any investigational drug or investigational vaccine from V1 through V8= Day 421.
• •12. Receipt or planned receipt of any licensed vaccine from V1 through V6= Day 70, except for SARS-Cov-2 vaccines recommended by national vaccination programs which will be allowed if given \> 28 days before and from the time of administration of clinical trial product.
• •13. Receipt of treatment likely to modify the immune response (e.g. blood products, immunoglobulins, immunosuppressive treatment) within 42 days before V3= Day 0 through V6= Day 70. Inhaled and topical corticosteroids are permitted.
• •14. Has a body mass index (BMI) \< 13 (weight, kg / height, m2) on the date of V1.
• •15. Female participants of childbearing potential (not sterilized, menstruating or within 1 year of last menses, if post-menopausal): if not willing to use an acceptable method to avoid pregnancy (sterile sexual partner, sexual abstinence, hormonal contraceptives (oral, injection, transdermal patch, or implant) or intrauterine device from 28 days before V3= Day 0 until 2 months after the 2nd vaccination.
• •16. Female participants: if lactating / nursing, or pregnant as per positive pregnancy test on V2.
• •17. Not suitable for inclusion in the opinion of the investigator.