1. Pregnant, breast-feeding, or unwilling to use medically-approved contraception

2. Currently using varenicline, bupropion or nicotine replacement therapy for smoking cessation

3. Medical disease that would preclude participation

4. Unstable psychiatric conditions

5. Body mass index (BMI) \< 15 or \> 38 kg/m2

6. Past-month suicidal intention, with or without a specific plan

7. Positive urine drug screen or breath alcohol level \> 0.01% at screening

Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1