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Effects of Emotional Stimuli in Patients With Disorders of Consciousness | Clinical Trials | Clareo Health

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Effects of Emotional Stimuli in Patients With Disorders of Consciousness

Effects of Emotional Stimuli in Patients With Disorders of Consciousness: An Electroencephalography and Neuroimaging Study

NCT03502837•First Affiliated Hospital of Zhejiang University

View on ClinicalTrials.gov

Summary

Disentangling the vegetative state from the minimally conscious state is often difficult when relying only on behavioral observation. In this study, the investigators explored a new event-related potential paradigm as an alternative method for the detection of voluntary brain activity and cognitive abilities in the patients with disorders of consciousness.

Detailed Description

Auditory emotional stimuli have potential beneficial effects on cognitive functions and consciousness in patients with disorders of consciousness (DOC); however, precise and accurate quantitative indices to estimate cerebral activation to different auditory stimuli remain scarce. In this study, investigators assessed the response of different brain regions to emotional stimuli using ERP(Event-related potential),and further investigated the brain activation network.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Patients:
•1. Disorders of consciousness (Traumatic brain injury, stroke or anoxic encephalopathy)
•2. Coma diagnosis (Plum and Posner, 1966), vegetative state (Task Force, 1994) or minimally conscious state (Giacino, Ashwal et al. 2002)
•3. Lack of autonomic crisis since one week minimum
•4. Medical condition considered stable
•5. Patients who do not present hearing loss. Peaks I and II of Brainstem Auditory Evoked Potentials (BAEP) will be normal.
•1. Subjects with normal hearing
•2. Absence of neurological disorder
•3. Subjects able to understand the experimental instructions

Exclusion Criteria

•1. hearing Problem
•2. Uncontrolled Epilepsy
•3. Autonomic crises
•4. Medical unstable state
•5. Pregnant or likely to be (interrogation data) or breastfeeding woman
•Healthy controls:
•1. Hearing problems and / or hearing loss higher than 30 decibels Hearing Level (dB HL) at a frequency band from 250 to 8000 Hz
•2. Neurological disorders
•3. Pregnant or likely to be (interrogation data) or breastfeeding woman

Locations (1)

Hangzhou Hospital of Zhejiang CAPR

Hangzhou, Zhejiang, China

Key Dates

Start Date

February 1, 2015

Primary Completion Date

July 30, 2017

Completion Date

August 30, 2017

Last Updated

April 19, 2018

Enrollment

ACTUAL participants

Conditions

Disorder of Consciousness

Interventions

emotional sound and neutral sound

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 19, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effects of Emotional Stimuli in Patients With Disorders of Consciousness

Inclusion Criteria

Exclusion Criteria

Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases

HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness

Vagal Nerve Stimulation to Treat Disorders of Consciousness

Safety and Efficacy of tDCS in Pediatric DoC

Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients

Amantadine for Neuroenhancement in Acute Patients Study