Innate Neutrophilic Nasal Inflammation in a Pollen Exposure Chamber

Inclusion Criteria

• •1. Participant demonstrates understanding of the study and has provided an appropriately signed and dated informed consent.
• •2. Male or Female, 18 to 70 years of age, at time of the Screening visit.
• •3. Positive allergic participants must have a history of at least moderate AR due to hypersensitivity to ragweed pollen for a minimum of 2 years prior to the Screening visit.
• •4. Positive allergic participants must respond to the ragweed pollen through a standard SPT administered at the Screening visit. A positive SPT is defined as a specified aeroallergen wheal diameter of at least 5 mm or larger than the negative control (normal saline). A historical SPT performed within three-hundred sixty-five (365) days or one (1) year will be accepted in lieu of performing a new SPT.
• •5. Normal negative control participants must have no medical history suggestive of chronic or recurrent nasal and ocular symptoms secondary to allergy to the ragweed pollen.
• •6. Normal negative control participants must demonstrate a negative SPT to the ragweed pollen at the Screening visit. A historical SPT performed within three-hundred sixty-five (365) days or one (1) year will be accepted in lieu of performing a new SPT.
• •7. Subject understands and is willing, able and likely to comply with study procedures and restrictions.
• •8. Subject, if female of child bearing potential, must have a negative urine pregnancy test at Visit 1. All females of child bearing potential must agree to a medically acceptable form of birth control throughout the study duration and for at least 1 month prior to Visit 1. Acceptable methods of birth control for this study include:
• •1. oral, patch, or intra-vaginal contraceptives
• •2. Norplant System®
• •3. Depo-Provera®
• •4. Intrauterine device (IUD)
• •5. double barrier method
• •6. abstinence
• •7. surgically sterile females (hysterectomy or tubal ligation)
• •8. \> 1 year post-menopausal females
• •9. abstinence
• •9. Other than SAR, participant is healthy as determined by pre-study medical history, physical examination and vital signs. Any chronic conditions that may interfere with the study outcomes or the subject's safety will be considered clinically significant and a reason for exclusion.
• •10. Subject must be able to read, comprehend, and record all information in English.