Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Imperial College London
With
Queen's University, Belfast
University of Southampton
University of Birmingham
University College, London
University of Nottingham
University of Edinburgh
University of Manchester
Nanyang Technological University
Age
30–45
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subjects eligible for enrolment in the study must meet all the following criteria:
Informed Consent: Subjects must give their signed and dated written informed consent to participate
Gender: Male or female subjects
Age: 30-45 years of age at screening
Smokers of at least 10 pack years
Have either normal lung function or mild lung function abnormalities
Subject groups will have one of the following:
* A. Subjects (smokers) with mild airflow limitation defined as an FEV1/FVC ratio \<lower limit of normal and FEV1 \> 80% of predicted normal and no symptoms. This group will make up at least 30% of the total cohort.
* B. Subjects (smokers) with mild airflow limitation as defined above and presence of respiratory symptoms defined as presence of chronic cough and/or chronic sputum and/or breathlessness equivalent to mMRC Grade 1 or higher. This group will make up no more than 25% of the total cohort.
* C. Subjects (smokers) with normal lung function defined as FEV1/FVC \> lower limit of normal and FEV1 \> 80% of predicted normal, with or without symptoms. This group will make up at least 30% of the total cohort.
You may not be if
Individuals currently diagnosed and treated for asthma will be excluded from the study, but individuals with a past history of childhood wheezing and of asthma may be included provided that they did not previously receive regular maintenance inhaled therapy with inhaled corticosteroids'
Subjects with another known chronic respiratory disease - other than mild airflow limitation as defined above, predominantly cannabis or shisha smokers
Clinically relevant abnormal laboratory values available at the screening assessment that could interfere with the objectives of the study or safety of the volunteer.
Subjects who are actively enrolled in an interventional clinical trial
Subjects with BMI \>35
Female participants who are pregnant or breastfeeding.
