A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events

Exclusion Criteria

• •ATR, AAD and RD cohorts:
• •\- Participants who experience the index event while within a time-at-risk window for more than one exposure type. (The exposure types in this study include FQ as a class, amoxicillin, azithromycin, trimethoprim, trimethroprim/sulfamethoxazole, and febrile illness not treated with antibiotics. Events while within a time-at-risk window of two or more exposure types cannot be associated with any one exposure. Participants are therefore excluded from the study)
• •For ATR and AAD cohorts:
• •Have inherited disorders of connective tissue, specifically: Ehlers-Danlos syndrome, epidermolysis bullosa, Marfan syndrome, osteogenesis imperfecta
• •Have an ATR or AAD event prior to index, during the 1-year pre-index period
• •For RD cohort:
• •Have cataract surgery prior to index
• •Have iridotomy or iridectomy prior to index