TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

Exclusion Criteria

• •1. Is under consideration for withdrawal of life-sustaining treatments within the next 72 hours.
• •2. Has had major esophageal or gastric surgery or direct luminal trauma on this admission (participants with lower abdominal surgery are not excluded unless enteral feeding is contraindicated).
• •3. Has mechanical bowel obstruction, short bowel syndrome, or the presence of an active gastric pacemaker.
• •4. Have pre-existing hepatic disease that meets Child-Pugh Class B (moderate; total score 7 to 9 points) or C (severe; total score 10 to 15 points).
• •5. Has been admitted primarily for treatment of a drug overdose.
• •6. Has a presence of a post-pyloric tube in place at Randomization that may be used for enteral nutrition.
• •7. Is receiving parenteral nutrition (PN) at Screening.
• •8. Is in diabetic ketoacidosis or non-ketotic hyperosmolar coma.
• •9. Has a different nutrient requirement than allowed in feeding protocol.(outside a range of 1.2 to 2 gram per kilogram per day \[g/kg/day\] of proteins and up to 1.5 kilocalorie per milliliter \[kcal/mL\]).