Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis

Inclusion Criteria

• •A clinical diagnosis of ankylosing spondylitis (AS) by treating rheumatologists, or a diagnosis of axial spondyloarthritis (axSpA) with a pelvis MRI with significant bone marrow edema on STIR sequences;
• •Minimum of 18 years old;
• •Are taking NSAIDs on a regular basis for AS or axSpA (defined as more than 20 days in the past month) and willing to withhold medication for one week; or having active symptoms that require initiation of NSAIDs;
• •Concomitant anti-rheumatic drugs are allowed, if the dose has been stable for the past three months;
• •Have active disease after initial washout period, defined by BASDAI \>=4/10, or back pain numerical rating scale (NRS)\>=4/10